Target-controlled infusion, or TCI, is a method of drug administration rapidly gaining popularity in the medical field. TCI involves using computerized systems to calculate and control the infusion rate of a drug to achieve a specific target concentration in the patient's bloodstream. The history and mechanics of TCI Enhancements in understanding the pharmacodynamics of opioids and anaesthetic drugs led to the development of TCI—a method of IV drug administration in the 1980s. Initially developed by Schüttler and Schwilden, TCI leverages sophisticated computer programs to predict the plasma concentration level at a given site and helps regulate the level of anaesthetic...